| 叶酸受体靶向的聚乳酸共聚物胶束的制备及性质研究 |
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| 引用本文： | 曹俊,吴瑶,陈元维,欧静,陈年操,罗祥林. 叶酸受体靶向的聚乳酸共聚物胶束的制备及性质研究[J]. 功能材料, 2010, 41(3) |
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| 作者姓名： | 曹俊 吴瑶 陈元维 欧静 陈年操 罗祥林 |
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| 作者单位： | 四川大学,高分子科学与工程学院,四川,成都,610065;四川大学,高分子科学与工程学院,四川,成都,610065;四川大学,高分子科学与工程国家重点实验室,四川,成都,610065 |
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| 基金项目： | 国家自然科学基金资助项目(30570486) |
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| 摘 要： | 叶酸偶联的羟脯氨酸-乳酸共聚物(PLLA-PHpr-FA)是一种新型的叶酸受体靶向生物降解聚合物,研究PLLA-PHpr-FA自组装形成胶束的能力及胶束的性质。临界胶束浓度(CMC)用芘荧光探针测定,结果表明,CMC很低并依赖于乳酸/羟脯氨酸的比例。透射电子显微镜(TEM)显示共聚物胶束呈现典型的核/壳结构。动态激光光散射(DLS)测定粒径及粒径分布结果显示,粒径受乳酸/羟脯氨酸比例和丙酮量调控,但粒子几乎不受稀释的影响。用紫外分光光度法测定胶束的载药量和包封率表明,共聚物胶束对疏水性药物的包载较好。因此,PLLA-PHpr-FA胶束可以作为肿瘤靶向的药物载体。
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| 关 键 词： | 叶酸 聚乳酸共聚物 胶束 疏水性药物 |
Preparation of folate receptor targeted micelles from polylactic acid copolymers and study on their properties |
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| CAO Jun,WU Yao,CHEN Yuan-wei,OU Jing,CHEN Nian-cao,LUO Xiang-lin. Preparation of folate receptor targeted micelles from polylactic acid copolymers and study on their properties[J]. Journal of Functional Materials, 2010, 41(3) |
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| Authors: | CAO Jun WU Yao CHEN Yuan-wei OU Jing CHEN Nian-cao LUO Xiang-lin |
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| Affiliation: | 1.College of Polymer Science and Engineering;Sichuan University;Chengdu 610065;China;2.State Key Laboratory of Polymer Materials Engineering;China |
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| Abstract: | The copolymer of L-lactide and 4-hydroxyproline with folate(PLLA-PHpr-FA) is a new kind of folate receptor targeted polylactic acid copolymers.This article aimed to research the self-assembly micelles and the properties of the micelles prepared from PLLA-PHpr-FA.The critical micelle concentration(CMC) was determined with fluorescent probe method,the results showed that the CMCs were quite low and dependent on the molar ratio of lactide/HP.Transmission electron microscope(TEM) indicated that the micelles pre... |
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| Keywords: | folate polylactic acid copolymer micelles hydrophobic drug |
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