Cytocompatibility property evaluation of gas pressure sintered SiAlON-SiC composites with L929 fibroblast cells and Saos-2 osteoblast-like cells |
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Authors: | Alok KumarAwadesh Kumar Mallik Nurcan Calis AcikbasMerve Yayg?ngol Ferhat KaraHasan Mandal Debabrata BasuKrishanu Biswas Bikramjit Basu |
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Affiliation: | a Department of Materials Science and Engineering, Indian Institute of Technology, Kanpur-208016, Indiab Central Glass and Ceramic Research Institute, CSIR, Kolkata-700032, Indiac MDA Advanced Ceramics, Ltd. Co., Eskisehir, Turkeyd Anadolu University, Department of Materials Science and Engineering, Eskisehir, Turkeye Sabanci University, Materials Science and Engineering Programme, Istanbul, Turkeyf Materials Research Centre, Indian Institute of Science, Bangalore - 560012, India |
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Abstract: | Although the oxide ceramics have widely been investigated for their biocompatibility, non-oxide ceramics, such as SiAlON and SiC are yet to be explored in detail. Lack of understanding of the biocompatibility restricts the use of these ceramics in clinical trials. It is hence, essential to carry out proper and thorough study to assess cell adhesion, cytocompatibility and cell viability on the non-oxide ceramics for the potential applications. In this perspective, the present research work reports the cytocompatibility of gas pressure sintered SiAlON monolith and SiAlON-SiC composites with varying amount of SiC, using connective tissue cells (L929) and bone cells (Saos-2). The quantification of cell viability using MTT assay reveals the non-cytotoxic response. The cell viability has been found to be cell type dependent. An attempt has been made to discuss the cytocompatibility of the developed composites in the light of SiC content and type of sinter additives. |
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Keywords: | SiAlON SiC Composite In vitro Cytocompatibility |
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