A generalized method for correcting instrument spreading in gel permeation chromatography

A general method of chromatogram correction for skewed instrument spreading in gel permeation chromatography is presented. The correction method is so general that there is no restriction on the shape of the spreading function. It admits nonsymmetric, non-Gaussian as well as nonconvolution type. Aspects of solution techniques are discussed and an illustrative example is given to elucidate the method.