Bioactive Lipids in Pathological Retinopathy |
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| Authors: | Qi Ma Jun-Hui Shen Sheng-Rong Shen Undurti N Das |
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| Affiliation: | 1. Department of Food Science and Nutrition , Zhejiang University , Hangzhou , 310029 , China;2. School of Medicine , Tongji University , Shanghai , 200092 , China;3. UND Life Sciences , Shaker Heights , OH , 44120;4. School of Biotechnology , Jawaharlal Nehru Technological University , Kakinada , 533 003 , India |
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| Abstract: | Diabetic retinopathy is a common condition that occurs in patients with diabetes with long-standing hyperglycemia that is characterized by inappropriate angiogenesis. This pathological angiogenesis could be a sort of physiological proliferative response to injury by the endothelium. Recent studies suggested that reactive oxygen species (ROS) play a significant role in this angiogenesis. Vascular endothelial growth factor (VEGF) is a potent angiogenic growth factor that plays a significant role in diabetic retinopathy. The interaction between VEGF and ROS, and theirs in turn with pro- and anti-inflammatory cytokines and anti-inflammatory bioactive lipid molecules such as lipoxins, resolvins, protectins, and maresins is particularly relevant to understand the pathophysiology of diabetic retinopathy and develop future therapeutic interventions. |
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| Keywords: | Reactive oxygen species vascular endothelial growth factor angiogenesis diabetic retinopathy lipoxins resolvins cytokines inflammation |
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