Meta-Review of Protein Network Regulating Obesity Between Validated Obesity Candidate Genes in the White Adipose Tissue of High-Fat Diet-Induced Obese C57BL/6J Mice |
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Authors: | Eunjung Kim Eun Jung Kim Seung-Won Seo Cheol-Goo Hur Robin A McGregor Myung-Sook Choi |
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Affiliation: | 1. Department of Food Science and Nutrition , Catholic University of Daegu , Gyeongsan , Republic of Korea;2. Center for Food &3. Nutritional Genomics, Department of Food Sciences and Nutrition , Kyungpook National University , Daegu , Republic of Korea;4. Department of Pharmacology and Dental Therapeutics , Chonnam National University School of Dentistry , Gwangju , Republic of Korea;5. University of Science and Technology , Daejeon , Korea;6. Bioinformatics Research Center, Korea Research Institute of Bioscience and Biotechnology , Daejeon , Republic of Korea;7. Center for Food & |
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Abstract: | Worldwide obesity and related comorbidities are increasing, but identifying new therapeutic targets remains a challenge. A plethora of microarray studies in diet-induced obesity models has provided large datasets of obesity associated genes. In this review, we describe an approach to examine the underlying molecular network regulating obesity, and we discuss interactions between obesity candidate genes. We conducted network analysis on functional protein–protein interactions associated with 25 obesity candidate genes identified in a literature-driven approach based on published microarray studies of diet-induced obesity. The obesity candidate genes were closely associated with lipid metabolism and inflammation. Peroxisome proliferator activated receptor gamma (Pparg) appeared to be a core obesity gene, and obesity candidate genes were highly interconnected, suggesting a coordinately regulated molecular network in adipose tissue. In conclusion, the current network analysis approach may help elucidate the underlying molecular network regulating obesity and identify anti-obesity targets for therapeutic intervention. |
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Keywords: | Obesity nutrigenomics high-fat C57BL/6J mouse adipose tissue |
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