Laser diffraction particle sizing by wet dispersion method for spray-dried infant formula |
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| Authors: | Byung-Man Kwak Ji Eun Lee Jang-Hyuk Ahn Tae-Hong Jeon |
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| Affiliation: | 1. Université de Lorraine, Laboratoire d’Ingénierie des Biomolécules (LIBio), 2 av de la Forêt de Haye, TSA 40602, 54518 Vand?uvre-lès-Nancy, France;2. Nestle PTC Konolfingen, Nestle Strasse 3, 3510 Konolfingen, Switzerland;3. Centre de Recherche Public Gabriel Lippmann, Département SAM, 41, rue du Brill, L-4422 Belvaux, Luxembourg;4. Université de Lorraine, LCPME, Laboratoire de Chimie Physique et Microbiologie pour l''Environnement, UMR 7564, 54600 Villers les Nancy, France;1. Aerosol Research Laboratory, Dept. of Pharmaceutics, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran;2. Medicinal Plants Research Center, Tehran University of Medical Sciences, Tehran, Iran;1. School of Food and Nutritional Sciences, University College Cork, Cork, Ireland;2. Food Chemistry and Technology Department, Teagasc Food Research Centre, Moorepark, Fermoy, Co. Cork, Ireland;1. Pharmaceutical Sciences and Engineering Technology, Celgene Corp., Summit, New Jersey 07901;2. Small Molecule Design and Development, Eli Lilly & Co., Indianapolis, Indiana 46285;3. Drug Product Technologies, Amgen Inc., Thousand Oaks, California 91320;4. Global Statistical Sciences, Eli Lilly & Co., Indianapolis, Indiana 46285;5. Small Molecule Pharmaceutical Sciences, Genentech Inc., South San Francisco, California 94080;6. Engineering & Technology, Biogen, Cambridge, Massachussetts 02142;7. Drug Product Development, Abbvie Inc., North Chicago, Illinois 60064;1. Department of Pharmaceutics, Shanghai Eighth People''s Hospital, Shanghai 200235, China;2. School of Pharmacy, Jiangsu University, Jiangsu, Zhenjiang 212013, China |
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| Abstract: | A laser diffraction particle sizing method involving wet analysis could be adapted effectively to measure the accurate particle size distribution of a spray-dried infant formula. Polar, polar aprotic and non-polar solvents, such as ethanol, methanol, acetone, pentane, heptane and hexane, were tested as dispersants for wet analysis. Non-polar solvents such as pentane, heptane and hexane found to be suitable dispersant because the shape of the infant formula particles in non-polar solvents was similar before and after the measurement while the particles had dissolved in the other solvents. The particle size distributions (PSD) of the infant formula determined by laser diffraction (Malvern Master Sizer, UK) using the dry analysis method with air was unsuitable because some parts of the primary and aggregated infant formula particles had been destroyed. The PSD graph of the air dispersion was shifted toward a smaller particle size from that of hexane dispersion. Overall, it is believed that laser diffraction particle sizing involving wet analysis with non-polar solvents may provide a suitable particle sizing method for infant formula products that is better than an air dispersion method. |
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