Naloxone induces multiple effects on aversive Pavlovian conditioning in rabbits.

Five experiments examined the effects of iv naloxone treatment on aversive Pavlovian conditioning of eye-blink and heart-rate responses, and related unconditioned behaviors, in 143 male albino rabbits. Naloxone (NX) treatment before testing attenuated bradycardiac orienting responses to tones used as CSs. NX also attenuated conditioned bradycardia when administered either before or after training sessions, but it potentiated conditioned bradycardia during extinction of discriminative conditioning. NX did not influence acquisition or extinction of discriminative eye-blink conditioning or somatic or cardiac responses to shocks used as UCSs, but it did decrease locomotor activity. NX immediately after training sessions facilitated acquisition of eye-blink responses. It is concluded that NX influences aversive Pavlovian conditioning in more than one way: (a) During training, it appears to alter reception and processing of signals but does not affect subsequent development of somatic responses to the Pavlovian conditioning contingency. (b) After training, NX apparently affects consolidation of both somatic and autonomic conditioning. (c) NX also appears to delay extinction of Pavlovian conditioning; this effect may similarly involve changes in a stimulus-processing mechanism or in memory functions, but it apparently does not involve changes in somatomotor responsivity. (44 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)