Effect of chronic administration of fenfluramine and quipazine on body weight gain after ovariectomy and on brain serotonin receptor binding.

In Exp I, chronic fenfluramine administration prevented excess weight gain following ovariectomy in 24 female Long-Evans rats but did not alter weight gain in 27 sham-operated controls. Chronic quipazine treatment had no long-term effect on body weight. Fenfluramine treatment for 28 days produced a 13% decrease in [–3H]-serotonin binding to hypothalamic membranes and no change in [–3H]-spiroperidol binding to striatum. In Exp II with 10 female Sprague-Dawley rats, chronic fenfluramine had no effect on [–3H]-serotonin binding to diencephalon. Results are discussed in terms of central and peripheral mechanisms of action and tolerance to fenfluramine. (10 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)