Carbamazepine in the treatment of cocaine dependence: Subtyping by affective disorder. |
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Authors: | Brady, Kathleen T. Sonne, Susan C. Malcolm, Robert J. Randall, Carrie L. Simpson, Kit Dansky, Bonnie S. Roberts, James S. Brondino, Michael |
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Abstract: | Studies investigating carbamazepine (CBZ) in the treatment of cocaine dependence have been inconsistent. In this study, cocaine-dependent individuals with (n=57) and without (n=82) affective disorder were compared in a 12-week, double-blind, placebo-controlled trial. Urine drug screens (UDS) and self-report of drug use were collected weekly. Affective symptoms were measured monthly. Subjects receiving CBZ attended more medication sessions (p=.03). The CBZ-treated affective group had a trend toward fewer cocaine-positive UDS (p=.08) and a significantly longer time to first cocaine use (p=.06). CBZ treatment did not have any impact on cocaine use in individuals without affective disorders. (PsycINFO Database Record (c) 2010 APA, all rights reserved) |
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Keywords: | carbamazepine treatment affective disorder cocaine dependence placebo-controlled trial |
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