| Fmoc法肽合成中正交保护赖氨酸的研究进展 |
| |
| 引用本文： | 姜和,卢姜华,陆荣健.Fmoc法肽合成中正交保护赖氨酸的研究进展[J].重庆工学院学报,2011(4). |
| |
| 作者姓名： | 姜和 卢姜华 陆荣健 |
| |
| 作者单位： | 重庆理工大学药学与生物学院;重庆前沿生物技术有限公司; |
| |
| 基金项目： | 十一五科技重大专项资助项目(2009ZX09401-004) |
| |
| 摘 要： | 综述了各种用于Fmoc法肽合成赖氨酸的正交保护方法,这些保护方法对多肽的化学修饰起着十分重要的作用。介绍了各种正交保护赖氨酸的合成、脱除方法及在肽合成中的应用实例,分析了各种保护基的特点、相互间的互补性及不足之处。
|
| 关 键 词： | 正交保护 肽合成 赖氨酸 |
Development of Orthogonal Protection of Lysine in Fmoc-Based Strategy Peptide Synthesis |
| |
| JIANG He,LU Jiang-hua,LU Rong-jian.Development of Orthogonal Protection of Lysine in Fmoc-Based Strategy Peptide Synthesis[J].Journal of Chongqing Institute of Technology,2011(4). |
| |
| Authors: | JIANG He LU Jiang-hua LU Rong-jian |
| |
| Affiliation: | JIANG He1,2,LU Jiang-hua1,LU Rong-jian2 (1.School of Pharmacy and Bioengineering,Chongqing University of Technology,Chongqing 400050 China,2.Chongqing Frontier Biotechnologies Co.,LTD,Chongqing 400041,China) |
| |
| Abstract: | The paper summarized up each kind of orthogonal protection method of lysine for Fmoc-based peptide synthesis.The methods have been played an important role in the peptide modification.In the paper,it introduced each kind of method for orthogonal protection of lysine in synthesis and removal as well as application case in the peptide synthesis,and analyzed the characteristic for each kind of protective group,and complementarities as well as deficiencies among them. |
| |
| Keywords: | orthogonal protection peptide synthesis lysine |
| 本文献已被 CNKI 等数据库收录！ |
