Influence of fatty alcohol and other fatty acid derivatives on fatty acid uptake into rat intestinal epithelial cells |
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Authors: | Kaeko Murota Noriko Matsui Teruo Kawada Nobuyuki Takahashi Takafumi Shintani Kahori Sasaki Tohru Fushiki |
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Affiliation: | (1) Present address: Department of Nutrition, School of Medicine, The University of Tokushima, 770-8503 Tokushima, Japan;(2) Laboratory of Nutrition Chemistry, Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, 606-8502 Kyoto, Japan |
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Abstract: | We investigated the influence of various substrates on the uptake of long-chain fatty acid into IEC-6, rat intestinal epithelial
cell line. The uptake of 3H]oleic acid into IEC-6 cells was a saturable function of the oleic acid concentration. Long-chain fatty acids significantly
inhibited the oleic acid uptake into IEC-6 cells and shorter-chain fatty acids had little or no effect. Various fatty acid
esters suppressed the oleic acid uptake into IEC-6. Fatty alcohols also inhibited oleic acid uptake into IEC-6 and the length
of the carbon chain played an important role. These results suggest that long-chain fatty acid uptake was inhibited by the
substrates which had a structure similar to long-chain fatty acids, especially those with a long carbon chain. At least two
molecules, fatty acid translocase and fatty acid transport protein type 4, which are considered to be involved in the long-chain
fatty acid transport into the cell, were expressed on IEC-6 cells, supporting the existence of the carrier-mediated system
of long-chain fatty acid transport on IEC-6 cells. |
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