Modulated temperature differential scanning calorimetry for examination of tristearin polymorphism: 2. Isothermal crystallization of metastable forms |
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Authors: | Satish K Singh Ali Fathe Jalali Maggie Aldén |
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Affiliation: | (1) Department of Pharmaceutical Technology, Pharmacia and Upjohn AB, S-751 82 Uppsala, Sweden;(2) Department of Pharmaceutical Chemistry, Physical and Inorganic Chemistry, Biomedical Center, Uppsala University, S-751 23 Uppsala, Sweden |
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Abstract: | The transformations of tristearin were examined by modulated temperature differential scanning calorimetry (MTDSC) in order
to examine the utility of this technique. Tristearin has been used as a model polymorphic system, showing metastable phases
and complicated transformation routes occuring at relatively slow rates. The β′-forms generated by thermal treatment under
modulation do not differ significantly from those generated by the corresponding treatment without modulation. While the total
heat flow thermograms are similar, the deconvoluted reversing component shows that annealing, especially at 63°C, has a significant
effect on the crystal size and perfection of the solid phases formed. MTDSC also enables the melting of β′ to be separated
from the simultaneous crystallization of the β form as evidenced in the c
p component. Quantitative interpretations about such systems cannot be drawn from MTDSC at this point in time. |
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Keywords: | Crystallization differential scanning calorimetry metastable forms MTDSC modulated temperature oscillating phase behavior polymorphism triglycerides tristearin |
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