Uterine activity patterns in uterine rupture: a case-control study |
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Authors: | JP Phelan LM Korst DK Settles |
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Affiliation: | Respiratory Division, Royal Victoria Hospital, Montreal, Quebec, Canada. |
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Abstract: | The effects of methylprednisolone therapy on the susceptibility of dystrophin-deficient myofibers to contraction-induced injury were evaluated in the mdx mouse diaphragm model of Duchenne dystrophy. Mdx myofibers were abnormally vulnerable to injury induced by high-stress eccentric contractions. However, methylprednisolone therapy did not significantly alter the degree of contraction-induced injury. These data suggest that beneficial effects of corticosteroid therapy in Duchenne dystrophy are unlikely to be related to a change in the threshold for contraction-induced myofiber damage. |
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