Potential mechanism of kaempferol against Cu2+-induced oxidative stress through chelating activity and regulation of nuclear factorerythroid-2-related factor 2 signaling |
| |
Authors: | Gyo-Nam Kim Eui-Su Kim Young-In Kwon Hae-Dong Jang |
| |
Affiliation: | 2. Department of Food Science and Biotechnology, Kyungnam University, Changwon, Gyeongnam, 631-701, Korea 1. Department of Food and Nutrition, Hannam University, Daejeon, 305-811, Korea
|
| |
Abstract: | Metal ions play important roles in various biological processes of living systems. However, the generation of reactive oxygen species (ROS) is also closely linked with the participation of redox-active metal ions such as copper, iron, chromium, and cobalt ions. Excessive production of ROS by redox-active metal ions can cause oxidative stress and further oxidative stress-related diseases. This study shows the results of the antioxidant activity of kaempferol in both ORACOH· and Cu2+-treated HepG2 cells. Preventive mechanism of kaempferol in Cu2+-treated HepG2 cells is also elucidated. These results suggest that both cellular Cu2+-chelating activity and expression of phase II detoxifying enzymes such as HO-1 and GSTA2 through activating Nrf2 are required for cellular antioxidant activity of kaempferol in Cu2+-treated HepG2 cells. Our findings provide the scientific evidence for the development of Nrf2 targeting dietary antioxidant to prevent oxidative stressrelated conditions. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|