A biodegradable diblcok copolymer poly(ethylene glycol)‐block‐poly(L‐lactide‐co‐2‐methyl‐2‐carboxyl‐propylene carbonate): Docetaxel and RGD conjugation |
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| Authors: | Zhigang Xie Xiuli Hu Xuesi Chen Tiancheng Lu Shi Liu Xiabin Jing |
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| Affiliation: | 1. State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, People's Republic of China;2. Graduate School of Chinese Academy of Sciences, Beijing 100039, People's Republic of China |
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| Abstract: | A diblcok copolymer monomethoxy poly (ethyleneglycol)‐block‐poly(L ‐lactide‐co‐2‐methyl‐2‐carboxyl‐propylene carbonate) (MPEG‐b‐P(LA‐co‐MCC)) was obtained by copolymerization of L ‐lactide (LA) and 2‐methyl‐2‐benzoxycarbonyl‐propylene carbonate (MBC) and subsequent catalytic hydrogenation. The pendant carboxyl groups of the copolymer MPEG‐b‐P(LA‐co‐MCC) were conjugated with antitumor drug docetaxel and tripeptide arginine‐glycine‐aspartic acid (RGD), respectively. 1H‐NMR spectra confirmed the structure of the copolymer MPEG‐b‐P(LA‐co‐MCC/docetaxel) and MPEG‐b‐P(LA‐co‐MCC/RGD). In vitro antitumor assay indicates that the MPEG‐b‐P(LA‐co‐MCC/docetaxel) conjugate shows high cytotoxic activity against HeLa cancer cells. Cell adhesion and spreading experiment shows that copolymer MPEG‐b‐P(LA‐co‐MCC/RGD) is of benefit to cell adherence and is a promising biodegradable material for cell and tissue engineering. © 2008 Wiley Periodicals, Inc. J Appl Polym Sci, 2008 |
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| Keywords: | biodegradable block copolymers docetaxel RGD |
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