Structure-activity relationships of non-peptide vasopressin V1a antagonists: 1-(1-multi-substituted benzoyl 4-piperidyl)-3,4-dihydro-2(1H)-quinolinones |
| |
Authors: | K Kondo H Ogawa K Nakaya M Tominaga Y Yabuuchi |
| |
Affiliation: | Second Institute of New Drug Research, Otsuka Pharmaceutical Co., Ltd., Tokushima, Japan. |
| |
Abstract: | During our systematic studies on the arginine vasopressin receptor V1a-antagonistic activity of 1-(1-benzoyl substituted 4-piperidyl)-3,4-dihydro-2(1H)-quinolinones, we found a general substituent effect on the benzene ring. Hydrogen-bonding ability at the ortho position was especially important for enhancement of the affinity of multi-substituted analogs. Details of the syntheses and structure-activity relationships for this series are presented. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|