| 3-氰基-1H-吡啶酮类化合物的合成及其反应机理的探讨 |
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| 引用本文： | 黄龙,潘洁,黄强,葛燕丽,巨修练. 3-氰基-1H-吡啶酮类化合物的合成及其反应机理的探讨[J]. 武汉化工学院学报, 2010, 0(3): 40-43 |
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| 作者姓名： | 黄龙 潘洁 黄强 葛燕丽 巨修练 |
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| 作者单位： | 武汉工程大学化工与制药学院绿色化工过程省部共建教育部重点实验室; |
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| 摘 要： | 以氰乙酰胺和N取代氰乙酰胺为原料分别与3－苯基4－N，N－二甲基3烯－2酮环合制备了6个3氰基－1H－吡啶酮类化合物，目标化合物结构均经^1HNMR和MS表征．并探讨了采用氰乙酰胺和N－取代氰乙酰胺分别进行环合时其环合方向不同的反应机理．
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| 关 键 词： | 氰乙酰胺 吡啶酮 环合反应 |
Synthesis of 3-cyano-2(1H)-pyridone compounds and the mechanism of cyclization |
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| HUANG Long,PAN Jie,HUANG Qiang,GE Yan-li,JU Xiu-lian. Synthesis of 3-cyano-2(1H)-pyridone compounds and the mechanism of cyclization[J]. Journal of Wuhan Institute of Chemical Technology, 2010, 0(3): 40-43 |
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| Authors: | HUANG Long PAN Jie HUANG Qiang GE Yan-li JU Xiu-lian |
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| Affiliation: | HUANG Long,PAN Jie,HUANG Qiang,GE Yan-li,JU Xiu-lian(Key Laboratory for Green Chemical Process of Ministry of Education,School of Chemical Engineering , Pharmacy,Wuhan Institute of Technology,Wuhan 430074,China) |
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| Abstract: | Six 3-cyano-2(1H)-pyridone compounds were obtained using cyanoacetamide and N-subtituted cyanoacetamides reacted with 4-(dimethylamino)-3-phenylpent-3-en-2-one respectively.All of the target compounds have been confirmed by 1H NMR,MS spectrums.In addition,the possible mechanisms of the two cyclization routes were discussed. |
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| Keywords: | cyanoacetamide pyridine cyclization |
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