| 尼泊尔黄堇中总生物碱的串联质谱分析 |
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| 引用本文： | 傅予,梁健,白央,达娃卓玛,白冰如,丁立生.尼泊尔黄堇中总生物碱的串联质谱分析[J].质谱学报,2010,31(2):98-102. |
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| 作者姓名： | 傅予 梁健 白央 达娃卓玛 白冰如 丁立生 |
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| 作者单位： | 1. 中国科学院成都生物研究所，四川 成都610041;2. 西藏自治区食品药品检验所，西藏 拉萨850000 |
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| 基金项目： | 国家自然科学基金项目 |
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| 摘 要： | 采用电喷雾串联质谱(ESI-MS/MS)法对尼泊尔黄堇中总生物碱进行分析。由一级质谱中各成分的准分子离子峰获知其相对分子质量,再由二级质谱的裂解碎片推测其结构特征。结合纯品的串联质谱分析,直接鉴定出从尼泊尔黄堇总生物碱中已经分离得到的10种异喹啉生物碱成分:stylopine(1),tetrahydrothalifendine(2),tetrahydroberberrubine(3),scoulerine(4),sinactine(5),protopine(6),cryptopine(7),α-allo-cryptopine(8),9-methyl-decumbenine C(9)和6-acetonyl-5,6-dihydrosanguinarine(10);另外还初步推测出2种未从该植物中分离得到的异喹啉生物碱成分。
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| 关 键 词： | 尼泊尔黄堇 异喹啉生物碱 串联质谱 |
Tandem Mass Spectrometry Analysis of Total Alkaloids from Corydalis hendersonii |
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| FU Yu,LIANG Jian,BAI Yang,DAWA Zhuo-ma,BAI Bing-ru,DING Li-sheng.Tandem Mass Spectrometry Analysis of Total Alkaloids from Corydalis hendersonii[J].Journal of Chinese Mass Spectrometry Society,2010,31(2):98-102. |
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| Authors: | FU Yu LIANG Jian BAI Yang DAWA Zhuo-ma BAI Bing-ru DING Li-sheng |
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| Affiliation: | 1. Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China；2. Tibet Autonomous Region Institute for Food and Drug Control, Lhasa 850000, China |
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| Abstract: | Electrospray ionization tandem mass spectrometry(ESI-MS/MS) was used to analyze the total alkaloids from Corydalis hendersonii. Based on the information of pseudo molecular ions and daughter ions, which were obtained from ESI-MS and tandem mass spectrometry, total of 10 main alkaloids are suggested as stylopine(1), tetrahydrothalifendine(2), tetrahydroberberrubine(3), scoulerine(4), sinactine(5), protopine(6), cryptopine(7), α-allocryptopine(8), 9-methyl-decumbenine C(9), and 6-acetonyl-5,6-dihydrosanguinarine(10), respectively. |
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| Keywords: | Corydalis hendersonii isoquinoline alkaloid tandem mass spectrometry |
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