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Inside Cover: Evaluation of tert‐Butyl Isosteres: Case Studies of Physicochemical and Pharmacokinetic Properties,Efficacies, and Activities (ChemMedChem 3/2015) |
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| Authors: | Matthias V. Westphal Bernd T. Wolfstädter Dr. Jean‐Marc Plancher Dr. John Gatfield Prof. Erick M. Carreira |
| Affiliation: | 1. Laboratorium für Organische Chemie, ETH Zürich, Vladimir‐Prelog‐Weg 3, 8093 Zürich (Switzerland);2. Competence Center for Systems Physiology and Metabolic Diseases, Schorenstrasse 16, 8603 Schwerzenbach (Switzerland);3. Pharmaceutical Research & Early Development, Roche Innovation Center Basel, F. Hoffmann‐La Roche Ltd. Grenzacherstrasse 124, 4070 Basel (Switzerland);4. Drug Discovery Biology, Actelion Pharmaceuticals Ltd. Gewerbestrasse 16, 4123 Allschwil (Switzerland) |
| Abstract: | |
| Keywords: | drug analogues isosterism metabolic stability pentafluorosulfanyl structure– property relationships |