生物催化生产手性环氧氯丙烷的研究进展

手性环氧氯丙烷(ECH)是一种高价值的手性合成子,在合成β-肾上腺素阻遏剂、维生素、费洛蒙等手性物质方面具有重要的作用。手性环氧氯丙烷的合成方法有化学法和生物法。化学法选择性差,重金属催化剂污染严重;生物法选择性较好,且环境友好。本文介绍了卤醇脱卤酶和环氧化物水解酶生产手性ECH的研究进展,并对其发展前景作了简要展望。

Progress in synthesis of chiral epichlorohydrin by biocatalytic conversion

Chiral epichlorohydrin （ECH）, a highly valuable chiral synthon, was used in the synthesis of a range of chiral products such as β-adrenergic blockers, vitamins and pheromones. It had been reported that ECH can be produced by both chemical and biological synthesis. Chemical synthesis had characteristics of low enantio-selectivity and serious pollution. However, biological methods were of high enantio-selectivity and environmentally-friendly. The synthesis of chiral epichlorohydrin by haloalcohol dehalogenases and epoxide hydrolases were reviewed in this paper.