| 活性干酵母与湿酵母催化不对称还原合成(R)-2-羟基-4-苯基丁酸乙酯的对比研究 |
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| 引用本文： | 王艳萍,夏咏梅.活性干酵母与湿酵母催化不对称还原合成(R)-2-羟基-4-苯基丁酸乙酯的对比研究[J].化学试剂,2009,31(4). |
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| 作者姓名： | 王艳萍 夏咏梅 |
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| 作者单位： | 1. 江南大学化学与材料工程学院,江苏,无锡,214036;江阴职业技术学院化学纺织工程系,江苏,江阴,214400
2. 江南大学化学与材料工程学院,江苏,无锡,214036 |
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| 摘 要： | 研究有机溶剂中面包酵母催化2-氧代-4-苯基丁酸乙酯(OPBE)不对称还原合成标题化合物((R)-HPBE),分别考察用干酵母和湿酵母作催化、底物浓度、反应体系和湿酵母保存时间等凶素对OPBE转化率(X<,OPBE>)、HPBE产率(Y<,HPBE>)及(R)-HPBE的光学纯度(e.e.%)的影响.实验结果表明,湿酵母的立体选择性好于干酵母,但转化率和产率很低;乙醚为湿酵母催化较为适宜的介质.另外,湿酵母培养好后应立即反应.
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| 关 键 词： | 面包酵母 不对称还原 (R)-2-羟基-4-苯基丁酸乙酯 |
Comparison study on enantioselective synthesis of ethyl(R)-2-hydroxy-4-phenylbutyrate mediated by Saccharomyces cerevisiae |
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| WANG Yan-ping,XIA Yong-mei.Comparison study on enantioselective synthesis of ethyl(R)-2-hydroxy-4-phenylbutyrate mediated by Saccharomyces cerevisiae[J].Chemical Reagents,2009,31(4). |
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| Authors: | WANG Yan-ping XIA Yong-mei |
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| Affiliation: | 1.School of Chemical and Material Engineering;Southern Yangtze University;Wuxi 214036;China;2.Chemistry & Textile Engineering Department;Jiangyin Polytechnic College;Jiangyin 214400;China |
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| Abstract: | The asymmetric reduction of ethyl-2-oxo-4-phenylbutyrate(OPBE)catalyzed by bakers' yeast(Saccharomyces cerevisiae) in organic solvent to synthesize optically active ethyl-2-hydroxy-4-phenylbutyrate(HPBE) was investigated in detail,and factors such as the yeast type,the concentration of substrates,the reaction system,and the preservation time of cultured yeast were studied.The experimental results indicated that the stereo-selectivity of cultured yeast was better than that of dry yeast.But its conversion rat... |
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| Keywords: | Saccharomyces cerevisiae asymmetric reduction chiral ethyl-2-hydroxy-4-phenylbutyrate |
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