| (R)-2-羟基苯丙酸苄酯合成方法改进 |
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| 引用本文： | 许艳杰,李美玲,陈立功. (R)-2-羟基苯丙酸苄酯合成方法改进[J]. 精细化工, 2006, 23(11): 1122-1124 |
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| 作者姓名： | 许艳杰 李美玲 陈立功 |
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| 作者单位： | 天津大学,化工学院,天津,300072;天津大学,药物科学与技术学院,天津,300072 |
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| 摘 要： | 对(R)-2-羟基苯丙酸苄酯的合成进行了探讨,分别采用BnOH-TosOH法,收率为57%;BnB r-Et3N法,收率30%;BnB r-Cs2CO3法,收率最高为82%;用廉价的K2CO3、Na2CO3代替Cs2CO3进行反应,也顺利得到产品,方法改进后的收率分别为55%、76%。
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| 关 键 词： | (R)-2-羟基苯丙酸苄酯 酯化 溴化苄 |
| 文章编号： | 1003-5214（2006）11-1122-03 |
| 收稿时间： | 2006-04-05 |
| 修稿时间： | 2006-04-052006-04-30 |
Improvement in the Syntheses of (R)-2-Hydroxyl-3-phenylpropanoic Acid Benzyl Ester |
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| XU Yan-Jie,LI Mei-Ling,CHEN Li-Gong. Improvement in the Syntheses of (R)-2-Hydroxyl-3-phenylpropanoic Acid Benzyl Ester[J]. Fine Chemicals, 2006, 23(11): 1122-1124 |
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| Authors: | XU Yan-Jie LI Mei-Ling CHEN Li-Gong |
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| Affiliation: | 1. School of Chemical Engineering and Technology, Tianjin University, Tianfin 300072, China; 2. College of Pharmaceuticals and Biotechnology , Tianjin University, Tianjin 300072, China |
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| Abstract: | Synthesis of(R)-2-hydroxyl-3-phenylpropanoic acid benzyl ester was studied using BnOH-TosOH in 57% yield,using BnBr-Et_3N in 30% yield,and using BnBr-Cs_2CO_3 in the highest yield of 82%.In order to improve the method,the product was obtained successfully using the cheap K_2CO_3 or Na_2CO_3 instead of Cs_2CO_3 in 55% or 76% yield respectively. |
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| Keywords: | (R)-2-hydroxyl-3-phenylpropanoic acid benzyl ester esterification benzyl bromide |
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