Effect of different CaSO4 contents on CaSiO3-CaSO4 porous composite bone scaffolds by 3D gel-printing |
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| Authors: | Huiping Shao Xinding Yu Zhinan Zhang Tao Lin Jiang Peng Aiyuan Wang Shuwen Liu Manjian Zhao |
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| Affiliation: | 1. Institute for Advanced Materials and Technology, University of Science and Technology Beijing, Beijing, China;2. Institute of Orthopedics, Chinese PLA General Hospital, Beijing, China Key Laboratory of Regenerative Medicine in Orthopedics, Key Laboratory of Musculoskeletal Trauma and War Injuries PLA, Beijing, China |
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| Abstract: | Porous CaSiO3-CaSO4 composite scaffolds were successfully prepared by 3D gel-printing (3DGP) technology in this study. In order to further improve the degradation performance of pure CaSiO3 scaffolds, the effect of different CaSO4 doping contents on CaSiO3-CaSO4 composite scaffolds was studied. The results show that when the porous composite scaffolds were placed in simulated body fluid (SBF) for 5 weeks, the weight loss rate was 2.41% (CaSiO3-1%CaSO4), 3.97% (CaSiO3-3%CaSO4), 4.18% (CaSiO3-5%CaSO4), 6.87% (CaSiO3-7%CaSO4), and 12.93% (CaSiO3-9%CaSO4), respectively, which could be concluded that CaSO4 doping has a significant effect on improving the biodegradability of CaSiO3 scaffolds. And CaSO4 doping can also effectively improve the compressive strength of composite scaffolds and that of CaSiO3-3%CaSO4 composite scaffolds was tested as 54.67 MPa, and the shrinkage rate of porous composite scaffolds was nearly 11.4%, which meets the application requirements of bone repairing engineering. |
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| Keywords: | 3DGP biodegradability CaSiO3 CaSO4 porous scaffolds |
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