Biocompatible green tea extract-stabilised zinc nanoparticles encapsulated by poly(butyl-2-cyanoacrylate) with control release profile and antioxidative capacity |
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Authors: | Jing-Jing Yao Peng Zhang Zhou-Ping Fu Zhong-Wen Xie Guan-Hu Bao |
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Affiliation: | 1. Natural Products Laboratory, International Joint Laboratory of Tea Chemistry and Health Effects, State Key Laboratory of Tea Plant Biology and Utilization, Anhui Agricultural University, 130 West Changjiang Road, Hefei, Anhui Province, 230036 China School of Medicine, Anhui University of Science and Technology, Huainan, Anhui Province, 232001 China;2. Natural Products Laboratory, International Joint Laboratory of Tea Chemistry and Health Effects, State Key Laboratory of Tea Plant Biology and Utilization, Anhui Agricultural University, 130 West Changjiang Road, Hefei, Anhui Province, 230036 China |
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Abstract: | Green tea extract-stabilised Zn nanoparticles (GT-Zn NPs) encapsulated by poly(butyl-2-cyanoacrylate) (PBCA@GT-Zn NPs) were developed for control release of Zn. The crucial parameters, concentrations of GT-Zn NPs and the monomer n-butyl-2-cyanoacrylate (BCA), which affected the size, polydispersity indexes (PDI) and encapsulation efficiency (EE %), were evaluated to achieve the smaller size, higher EE (%) and stably and uniformly dispersed NPs. The optimised PBCA@GT-Zn NPs with <100 nm diameter (46.38 ± 3.46 by SEM, 86.91 ± 3.66 by DLS), PDI (0.159 ± 0.042), zeta potential (−20.56 ± 2.53 mV) and EE (89.31 ± 1.09 %) were obtained. In vitro release of Zn ions was conducted at pH 7.4, showing that Zn from the self-made tablets and lyophilised PBCA@GT-Zn NPs is released significantly slower than that of GT-Zn NPs. Additionally, the PBCA@GT-Zn NP tablets are pH-responsive, non-toxic and antioxidative, suggesting that they could be used as safe food material or drug carriers, contributing to relieve Zn deficiency. |
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Keywords: | Antioxidation control release cytotoxicity green tea extract poly(butyl-2-cyanoacrylate) zinc deficiency |
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