Short communication: Algicide activity of antimicrobial peptides compounds against Prototheca bovis |
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| Authors: | V.R. Sperotto L.B. Denardi C. Weiblen F.P.K. de Jesus M.R. Dorneles L.B. Ianiski J.M. Santurio |
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| Affiliation: | 1. Pharmacology Postgraduate Program, Federal University of Santa Maria, Rio Grande do Sul, Brazil, 97105-900;2. University of Cruz Alta, Cruz Alta, Rio Grande do Sul, Brazil, 98005-972;3. Department of Microbiology and Parasitology, Federal University of Santa Maria (UFSM), Santa Maria, RS, Brazil, 97105-900;4. Postgraduate Program in Pharmaceutical Sciences, Federal University of Santa Maria, Rio Grande do Sul, Brazil, 97105-900 |
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| Abstract: | This study evaluated the in vitro activity of antimicrobial peptides pexiganan (MSI-78), h-Lf1–11, LL-37, cecropin B, magainin-2, and fengycin B against the veterinary mastitis agent Prototheca bovis. The results showed that pexiganan, h-Lf1–11, LL-37, and cecropin B were able to inhibit the growth and had effect on algicide P. bovis isolates (n = 32). The minimum inhibitory concentration ranged from 5 to 10 µg/mL for pexiganan, and algicide effect was detected from 5 to 20 µg/mL. The minimum inhibitory concentration ranged from 10 to 80 µg/mL for h-Lf1–11, 20 to 80 µg/mL for LL-37, and 40 to 160 µg/mL for cecropin B. These findings present a promising and novel alternative for P. bovis treatment and growth control. |
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| Keywords: | protothecosis antimicrobial peptides h-Lf1-11 cecropin B |
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