In vitro activity of Δ6 and Δ9 desaturases in hepatomas of different growth rates |
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| Authors: | L E Chiappe M E De Tomas O Mercuri |
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| Affiliation: | 1. Cátedra de Bioquímica Instituto de Fisiología, Facultad de Ciencias Médicas, La Plata, Argentina
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| Abstract: | The in vitro activity of Δ9- and Δ6-desaturases was determined in the microsomal fraction of C3H/S normal mouse liver, SS1K fast growing hepatoma, and SS1H slow growing hepatoma. These tumors are two different sublines of a spontaneous hepatoma transplanted in 1949 by J.W. Wilson, Brown University, Providence, R.I., into C3H/ST W: strain. The activity of the two enzymes showed a parallel decrease in the two studied hepatomas. These alterations could be attributed to a fundamental change in structure or function in the tumors. The fatty acid desaturase activity seems to be independent of cell division in malignant tissues. |
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