Experimental determination of the respiratory tract deposition of diesel combustion particles in patients with chronic obstructive pulmonary disease |
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Authors: | Jakob L?ndahl Erik Swietlicki Jenny Rissler Agneta Bengtsson Christoffer Boman Anders Blomberg Thomas Sandstr?m |
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Affiliation: | 1. Department of Physics, Division of Nuclear Physics, Lund University, P.O. Box 118, 221 00, Lund, Sweden 2. Department of Design Sciences, Division of Ergonomics and Aerosol Technology (EAT), Lund University, P.O. Box 118, 221 00, Lund, Sweden 3. Energy Technology and Thermal Process Chemistry, Ume? University, 901 87, Ume?, Sweden 4. Department of Public Health and Clinical Medicine, Division of Medicine/Respiratory Medicine, Ume? University, 901 87, Ume?, Sweden
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Abstract: | Background Air pollution, mainly from combustion, is one of the leading global health risk factors. A susceptible group is the more than 200 million people worldwide suffering from chronic obstructive pulmonary disease (COPD). There are few data on lung deposition of airborne particles in patients with COPD and none for combustion particles. Objectives To determine respiratory tract deposition of diesel combustion particles in patients with COPD during spontaneous breathing. Methods Ten COPD patients and seven healthy subjects inhaled diesel exhaust particles generated during idling and transient driving in an exposure chamber. The respiratory tract deposition of the particles was measured in the size range 10?C500?nm during spontaneous breathing. Results The deposited dose rate increased with increasing severity of the disease. However, the deposition probability of the ultrafine combustion particles (< 100?nm) was decreased in COPD patients. The deposition probability was associated with both breathing parameters and lung function, but could be predicted only based on lung function. Conclusions The higher deposited dose rate of inhaled air pollution particles in COPD patients may be one of the factors contributing to their increased vulnerability. The strong correlations between lung function and particle deposition, especially in the size range of 20?C30?nm, suggest that altered particle deposition could be used as an indicator respiratory disease. |
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