Atherogenesis in swine fed several types of lipid-cholesterol diets |
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Authors: | Dale P J Goldsmith Herbert P Jacobi |
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Affiliation: | (1) Department of Biochemistry, University of Nebraska, College of Medicine, 68105 Omaha, Nebraska |
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Abstract: | Eighteen-month-old Nebraska strain minipigs were fed diets containing 2% cholesterol and 20% corn oil, lard, or coconut oil
for 12 to 18 months. Concentrations of serum total lipid, total cholesterol, and total phospholipid increased 200 to 300%
with each diet. Changes in serum concentrations of Sf 20+ and Sf 0–20 lipoproteins varied with diets fed. Serum concentration of high density lipoprotein was increased in all cases. Intima
concentration of Sf 0–20 lipoprotein fraction was elevated by feeding the corn oil diet. There was no development of atherosclerosis as a result
of feeding the corn oil-cholesterol diet, but there was an increase in atherosclerosis as a result of feeding the lard or
coconut oil diet. There were no correlations between fatty acid patterns of several lipid fractions from serum and corresponding
lipid fractions from aortic intima of corn oil fed animals.
Deceased. |
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