单核细胞增生李斯特菌的毒力因子

目的单核细胞增生李斯特菌(Listeria monocytogenes,Lm)属于革兰阳性无芽孢杆菌李斯特菌属,主要通过食物传播。Lm的致病性与毒力因子密切相关,研究其毒力因子对认识致病机理有着重要意义。方法对Lm重要的毒力因子(溶血素、磷脂酶、内化素、肌动蛋白、P60蛋白等)进行综述。结果溶血素是一个多功能的毒力因子,对于Lm逃离吞噬细胞囊是必需的。Lm能产生两种磷脂酶C:磷脂酰肌醇磷脂酶C和磷脂酰胆碱磷脂酶C,协助细菌的细胞内复制。肌动蛋白使得Lm在宿主细胞间能够扩散。内化素与Lm的侵袭力有关。P60蛋白是Lm的主要免疫原性抗原。结论Lm毒力因子研究的深入对李斯特菌病的防治将带来深远的影响。

Virulence Factors of Listeria monocytogenes

Objective Listeria monocytogenes is a gram-positive,no spore,food-borne pathogen which causes listeriosis.This article reviews the significance of the virulence factors of L.monocytogenes,which are closely related to its pathogenicity.Method Papers relevant to the virulence factors of L.monocytogenes(for example,LLO,PLC,Inl,ActA,P60) were reviewed.Results LLO is a multi-purpose virulence factor and is essential for escaping from the phagocytic vesicle of the macrophage.L.monocytogenes can produce two kinds of PLC:PI-PLC and PC-PLC,which have also evolved for intracellular growth.ActA is required for its unidirectional actin-based motility within an infected host cell.Inl is related to the invasiveness of L.monocytogenes.The P60 protein is the main original antigen of L.monocytogenes.Conclusion A thorough research to the virulence factors will bring about great impact on the treatment and prevention of listeriosis.