Biochemistry of bacterial multidrug efflux pumps |
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Authors: | Kumar Sanath Varela Manuel F |
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Affiliation: | QC Laboratory, Post Harvest Technology Department, Central Institute of Fisheries Education (CIFE), Versova, Mumbai 400061 India; E-Mail: sanathkumar@cife.edu.in. |
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Abstract: | Bacterial pathogens that are multi-drug resistant compromise the effectiveness of treatment when they are the causative agents of infectious disease. These multi-drug resistance mechanisms allow bacteria to survive in the presence of clinically useful antimicrobial agents, thus reducing the efficacy of chemotherapy towards infectious disease. Importantly, active multi-drug efflux is a major mechanism for bacterial pathogen drug resistance. Therefore, because of their overwhelming presence in bacterial pathogens, these active multi-drug efflux mechanisms remain a major area of intense study, so that ultimately measures may be discovered to inhibit these active multi-drug efflux pumps. |
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Keywords: | efflux pump antibiotic resistance MFS antiporter Tet Qac |
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