N-(2-(5-溴-1H-吲唑-1-基)苯基)-2-氯烟酰胺的合成工艺研究 |
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作者单位: | ;1.铜仁学院材料与化学工程学院 |
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摘 要: | 采用单因素试验法对N-(2-(5-溴-1H-吲唑-1-基)苯基)-2-氯烟酰胺合成反应的反应条件进行了优化和研究,对关键步骤中间体I的合成确定了各个因素的最佳取值:反应时间为22h;物料配比应为5-溴吲唑:邻硝基氯苯:碳酸钾=1:0.85:1.15;反应温度为120℃;碱为碳酸铯。大大的提高了目标产物的总收率,为以后的大批量生产提供了有效途径。
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关 键 词: | 琥珀酸脱氢酶抑制剂 吲唑 工艺优化 正交试验 |
Study on Synthesis Technology of N-(2-(5-bromo-1H-indazol-1-yl)phenyl)-2-chloronicotinamide |
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Affiliation: | ,College of Material and Chemical Engineering,Tongren University |
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Abstract: | In this paper,the reaction conditions of N-(2-(5-bromo-1 H-indazol-1-yl)phenyl)-2-chloronicotinamide synthesis reaction were optimized and studied by single factor test,The optimum reaction time of each factor was determined for the synthesis of intermediate step I:reaction time was 22 h;the material ratio should be 5-bromoindazole:o-nitrochlorobenzene:potassium carbonate = 1:0.85:1.15;The temperature is 120 ° C;the base is cesium carbonate. Greatly improving the total yield of the target product,for the future mass production provides an effective way. |
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Keywords: | SDHIs indazole Process Optimization Orthogonal test |
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