Electrochemical behaviors and determination of isoniazid at ordered mesoporous carbon modified electrode |
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Authors: | Xue YanAuthor VitaeXiangjie BoAuthor Vitae Liping GuoAuthor Vitae |
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Affiliation: | Faculty of Chemistry, Northeast Normal University, Renmin Street 5268, Changchun, Jilin 130024, PR China |
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Abstract: | In this work, an electrochemical sensor based on ordered mesoporous carbon (OMC) for the amperometric detection of isoniazid was developed. OMC was dispersed in a solution of Nafion, and the suspension was modified onto the surface of glassy carbon (GC) electrode. Cyclic voltammetry and amperometry were used to investigate the electrochemical behaviors of isoniazid on Nafion-OMC modified electrode (Nafion-OMC/GC). The results indicate that OMC can facilitate the electrochemical oxidation of isoniazid with a great decrease of overpotential in pH 7.0 phosphate buffer solution. The proposed biosensor provides excellent performance towards the determination of isoniazid with a high sensitivity of 0.031 μA/μM, a low detection limit of 8.4 × 10−8 M and wide linear range from 1.0 × 10−7 M to 3.7 × 10−4 M at +0.20 V vs. Ag/AgCl. The method was successfully applied to the determination of isoniazid tablets with satisfying results. All the results suggest that Nafion-OMC/GC electrode is a potential candidate for a stable and efficient electrochemical sensor to detect isoniazid. |
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Keywords: | Ordered mesoporous carbon Isoniazid Electrochemical sensor Amperometric determination |
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