加速器直接生产99mTc的化学分离纯化研究现状

^99mTc（T_1/2＝6.01 h）是⁹⁹Mo的衰变子体，是目前核医学临床诊断应用最为广泛的放射性核素，其使用量约占所有诊断放射性同位素的80%。近年来，基于回旋加速器通过核反应¹⁰⁰Mo(p,2n)^99mTc直接生产^99mTc已经成为国际上比较认可的方法，具有不需要反应堆、无高浓缩铀、放射性废物少、不存在核扩散风险等优势。本文针对加速器直接生产技术所发展的几种^99mTc化学分离纯化方法进行了详细阐述，包括柱色谱分离、溶剂萃取、化学沉淀以及热色谱法。本工作可为我国开展加速器直接生产^99mTc提供一定的参考。

Current Status of Chemical Separation and Purification for Direct Production of 99mTc on Cyclotron Accelerator

Radioisotope ^99mTc (T_1/2＝6.01 h) is the decay daughter of ⁹⁹Mo, which is a widely used radioisotope in nuclear medicine. It accounts for about 80% of all radioactive isotopes used. Recently, the direct production of ^99mTc on cyclotron accelerators via ¹⁰⁰Mo(p,2n)^99mTc reaction has been the most promising approach with many advantages, such as nonreactors, no highly enriched uranium, less radioactive waste and no nuclear proliferation. This paper reviews the reported several separation strategies for ^99mTc based on cyclotron production, which includes column chromatography, solvent extraction, chemical precipitation and thermochromatography. This work could provide some theoretical reference for the investigation of direct production of 99mTc on cyclotron accelerator in China.