Dual Phase‐Controlled Synthesis of Uniform Lanthanide‐Doped NaGdF4 Upconversion Nanocrystals Via an OA/Ionic Liquid Two‐Phase System for In Vivo Dual‐Modality Imaging |
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| Authors: | Meng He Peng Huang Chunlei Zhang Hengyao Hu Chenchen Bao Guo Gao Rong He Daxiang Cui |
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| Affiliation: | Department of Bio‐Nano Science and Engineering, National Key Laboratory of Micro/Nano Fabrication Technology, Key Laboratory of Thin Film and Microfabrication Technology of Department of Education, Institute of Micro‐Nano Science and Technology, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, China |
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| Abstract: | A novel OA/ionic liquid two‐phase system combining the merits of thermal decomposition method, the IL‐based strategy, and the two‐phase approach is introduced to synthesize high‐quality lanthanide‐doped NaGdF4 upconversion nanocrystals with different crystal‐phases in OA‐phase and IL‐phase through a one‐step controllable reaction. Oil‐dispersible cubic‐phase NaGdF4:Yb, Er (Ho, Tm) nanocrystals with ultra‐small size (～5 nm) and monodispersity are obtained in the OA phase of the two‐phase system via an IL‐based reaction. More importantly, water‐soluble hexagonal‐phase NaGdF4:Yb, Er nanocrystals are obtained in the same system simply by adopting an extremely facile method to complete the dual phase‐transition (crystal‐phase transition and OA‐phase to IL‐phase transition) simultaneously. The synthesized lanthanide‐doped NaGdF4 upconversion nanocrystals are effective for dual‐mode UCL imaging and CT imaging in vivo. |
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| Keywords: | ionic liquid two‐phase phase transition rare‐earth nanocrystals upconversion luminescence |
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