Electrospinning Preparation and Drug‐Delivery Properties of an Up‐conversion Luminescent Porous NaYF4:Yb3+, Er3+@Silica Fiber Nanocomposite |
| |
Authors: | Zhiyao Hou Chunxia Li Pingan Ma Guogang Li Ziyong Cheng Chong Peng Dongmei Yang Piaoping Yang Jun Lin |
| |
Affiliation: | 1. State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China;2. Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Materials Science and Chemical Engineering, Harbin Engineering University, Harbin 150001, P. R. China |
| |
Abstract: | Up‐conversion (UC) luminescent porous silica fibers decorated with NaYF4:Yb3+, Er3+ nanocrystals (NCs) (denoted as NaYF4:Yb3+, Er3+@silica fiber) are prepared by the electrospinning process using cationic surfactant P123 as a template. Monodisperse and hydrophobic oleic acid capped β‐NaYF4: Yb3+, Er3+ NCs are prepared by thermal decomposition methodology. Then, these NCs are transferred into aqueous solution by employing cetyltrimethylammonium bromide (CTAB) as secondary surfactant. The water‐dispersible β‐NaYF4:Yb3+, Er3+ NCs are dispersed into precursor electrospinning solution containing P123 and tetraethyl orthosilicate (TEOS), followed by preparation of precursor fibers via electrospinning. Finally, porous α‐NaYF4:Yb3+, Er3+@silica fiber nanocomposites are obtained after annealing the precursor fibers containing β‐NaYF4:Yb3+, Er3+ at 550 °C. The as‐prepared α‐NaYF4:Yb3+, Er3+@silica fiber possesses porous structure and UC luminescence properties simultaneously. Furthermore, the obtained nanocomposites can be used as a drug delivery host carrier and drug storage/release properties are investigated, using ibuprofen (IBU) as a model drug. The results indicate that the IBU–loaded α‐NaYF4:Yb3+, Er3+@silica fiber nanocomposites show UC emission of Er3+ under 980 nm NIR laser excitation and a controlled release property for IBU. Meanwhile, the UC emission intensity of IBU–α‐NaYF4:Yb3+, Er3+@silica fiber system varies with the released amount of IBU. |
| |
Keywords: | electrospinning NaYF4 silica fiber up‐conversion drug delivery |
|
|