| 纳米HA/PA6复合材料的体外生物活性 |
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| 引用本文： | 严永刚,李玉宝,张利,彭雪林,许凤兰,王学江,杨晓庆. 纳米HA/PA6复合材料的体外生物活性[J]. 复合材料学报, 2004, 21(2): 147-152 |
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| 作者姓名： | 严永刚 李玉宝 张利 彭雪林 许凤兰 王学江 杨晓庆 |
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| 作者单位： | 四川大学生物纳米材料研究中心, 四川大学分析测试中心, 成都610064 |
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| 摘 要： | 研究了PA6和纳米HA/PA6复合材料在模拟体液(SBF)中的行为变化,用IR,XRD,SEM和EDS等手段对材料的表面变化进行了分析,讨论了PA6和纳米HA/PA6复合材料的稳定性、亲水性和生物活性。结果表明:在SBF中PA6的吸水率大概在6%左右,纳米HA/PA6复合材料的吸水率有少量下降,PA6和纳米HA/PA6复合材料出现一定的溶解和降解。在SBF中,PA6表面形成Ca,P化合物中的Ca/P比例为1.12,与HA的理论值1.67有一定的差别;HA/PA6复合材料在其表面形成了HA沉积物和碳酸取代的磷灰石沉积物,Ca/P逐步变化为1.67,表现出较好的生物活性。复合材料表面沉积的HA和原来合成的HA具有相近的结晶形貌,该复合材料可作为优良的骨修复填充材料和组织工程支架材料。
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| 关 键 词： | PA6 纳米HA 纳米HA/PA6复合材料 模拟体液 生物活性 |
| 文章编号： | 1000-3851(2004)02-0147-06 |
| 收稿时间： | 2003-05-19 |
| 修稿时间： | 2003-07-14 |
IN VITRO BIOACTIVITY OF PA6 AND NANO-HA/PA6 COMPOSITE |
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| YAN Yonggang,LI Yubao,ZHANG Li,PENG Xuelin,XU Fenglan,WANG Xuejiang,YANG Xiaoqing. IN VITRO BIOACTIVITY OF PA6 AND NANO-HA/PA6 COMPOSITE[J]. Acta Materiae Compositae Sinica, 2004, 21(2): 147-152 |
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| Authors: | YAN Yonggang LI Yubao ZHANG Li PENG Xuelin XU Fenglan WANG Xuejiang YANG Xiaoqing |
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| Affiliation: | Nano-biomaterials Research Centre,Analytical and Testing Centre, Sichuan University, Chengdu 610064, China |
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| Abstract: | The in vitro bioactivities of PA6 and nano-HA/PA6 were studied in SBF(simulated body fluid). The results show that PA6 was not bioactive in SBF, and Ca-P compound is slowly deposited on the surface of PA6, but it was not HA. Nano-HA/PA6 composite was chemically active in SBF, and dissolution and deposition of Ca, P ions happened during the culture in SBF. The Ca-P precipitate on the surface of HA/PA6 composite surface was carbonated-apatite. Its weight lost by about 2 % every week. This kind of composite could be one of the best potential bioactive materials for load-bearing bones, substitution or as bioengineering material. |
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| Keywords: | PA6 nano-hydroxyapatite HA/PA6 composite SBF bioactivity |
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