Monoolein-water liquid crystalline gels of gentamicin as bioresorbable implants for the local treatment of chronic osteomyelitis: in vitro characterization |
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Authors: | Ouédraogo Moustapha Semdé Rasmané Somé Issa Toudoridomou Traoré-Ouédraogo Rasmata Guissou Innocent Pierre Henschel Viviane Dubois Jacques Amighi Karim Evrard Brigitte |
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Affiliation: | UFR-Sciences de la Santé, Université de Ouagadougou, Ouagadougou, Burkina Faso. |
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Abstract: | To maximize the efficacy of chronic osteomyelitis antibiotherapy while reducing antibiotic systemic toxicity, as well as time and costs of hospitalizations, it has been thought that monoolein-water gels incorporating gentamicin sulfate could be used as local, bioresorbable,and sustained-release implants. For this purpose, four formulations were examined with regard to their physicochemical and in vitro drug release characteristics. Hot stage microscopy, differential scanning calorimetry (DSC), thermogravimetric analysis (TGA),and X-ray diffraction showed cubic liquid crystalline and eutectic structures. The more suitable formulation consisting of 80-15-5%wt/wt monoolein-water-gentamicin sulfate progressively released the antibiotic for a period of 3 weeks without burst effect. Moreover, the content and the release profile of gentamicin sulfate were not significantly changed after storage at 2-6 degrees C for a period of 10 months. |
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