重组牛碱性成纤维细胞生长因子治疗Ⅱ度烧伤的临床疗效

目的 观察重组牛碱性成纤维细胞生长因子（bFGF）对烧伤创面愈合的治疗作用。方法 选择浅Ⅱ度和深Ⅱ度烧伤病例共920例,分别用bFGF治疗其烧伤创面,用药剂量为144U/cm2观察伤后8d（浅Ⅱ度）和15d（深Ⅱ度）创面愈合率,以及创面完全愈合时间。结集8d愈合率总体治疗组为77.6％±24.4％,对照组为51.7％±26.4％;完全愈合时间总体治疗组为9.6±2.4d,对照组为12.6±2.9d。15d愈合率总体治疗组为75.2％±26.3％,对照组为53.3％±25.4％;完全愈合时间总体治疗组为17.5 ±4.5d,对照组为21.9±5.5d。结论 bFGF具有明显的促进Ⅱ度烧伤创面愈合的作用。

Curative Effect of Recombinant Bovine Basic Fibroblast Growth Factor on Burn Wound Degree Ⅱ

Objective To observe the curative effect of recombinant bovine basic fibroblast growth factor (bFGF) on burn wound degree II . Methods A total of 920 cases of burn wound of superficial or deep degree II were treated with bFGF at a dosage of 144U/cm, and the healing rate as well as the time for complete healing ,were observed 8(superficial degree II )and 15(deep degree II )days after treatment. Results The healing rates of superficial degree II bum wound of trial and control groups 8 days after treatment were (77.6 ± 24.4) % and (51.7±26.4)% ,and the time for complete healing of them were 9.6 ±2.4 and 12.6 ±2.9 days respectively. However,the healing rates of deep degree II bum wound of trial and control groups 15 days after treatment were( 75.2 ±26.3) % and (53.3± 25.4) % , and the time for complete healing of them were 17.5± 4.5 and 21.9±5.5 days respectively.Conclusion bFGF promotes the healing of burn wound degree H significantly.