| IR在新药沙纳唑结构确证中的应用 |
| |
| 引用本文： | 骆传环,黄荣清,舒融,宋占军,刘炳玉.IR在新药沙纳唑结构确证中的应用[J].现代仪器,2003(2):23-24,26. |
| |
| 作者姓名： | 骆传环 黄荣清 舒融 宋占军 刘炳玉 |
| |
| 作者单位： | 1. 军事医学科学院放射医学研究所,北京,100850
2. 国家生物医学中心,北京,100850 |
| |
| 基金项目： | 国家九五重点科技攻关项目(96-902-01-05) |
| |
| 摘 要： | 用IR对一类新药沙纳唑的化学结构进行确证,主要得到3403,3108,2995,1668,1555,1371和1145(cm~(-1))7个吸收峰,大部分是强的伸缩振动,分别代表分子结构中的-NH,=CH,-CH,-CONH,-NO_2(反称),-NO_2(对称)和-OCH_3官能团。结合NMR,UV,MS,X线衍射等测试结果,确证沙纳唑的结构式确实为N-(2-甲氧基乙基)-2-(3-硝基-1,2,4-三氮唑基-1-)乙酰胺。
|
| 关 键 词： | IR 沙纳哇 结构确证 |
Application of IR in chemical structure confirmation of a new drug Sanazole |
| |
| Luo Chuanhuan Huang Rongqing Shu Rong Song Zhan jun Liu Bingyu.Application of IR in chemical structure confirmation of a new drug Sanazole[J].Modern Instruments,2003(2):23-24,26. |
| |
| Authors: | Luo Chuanhuan Huang Rongqing Shu Rong Song Zhan jun Liu Bingyu |
| |
| Abstract: | Sanazole,N- (-2-methoxy ethyl-)-2- (3-nitro-l,2,4-triazole-l-yl-acetylamine is a new radiosensitizer. Its chemica structure was confirmed with IR as well UV,NMR,MS,X-ray diffraction analysis techniques,etc.There are seven peaks in IR spectnim:3403, 3108, 2995, 1668, 1555 , 1371, and 1145 (cnryhich are demonstracted separately as -NH,=CH,-CH2-,-CONH, -N02(unsymmetry),-N02-(symmetry)and -OCH3 in Sandazole molecular structre. |
| |
| Keywords: | IR Sanazole Structure confirmation |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
