Dissolution of a solid sphere in an unbounded, stagnant liquid |
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Authors: | R.G. Rice D.D. Do |
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Affiliation: | a Chemical Engineering Department, Louisiana State University, Baton Rouge, La: 70803, USA b Chemical Engineering Department, University of Queensland, St Lucia, Queensland 4072, Australia |
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Abstract: | An exact analytical solution is obtained for the transient dissolution of solid spheres in a diffusion-controlled environment. This result provides a useful reference point for drug testing in humans. The dimensionless solution is expressed in terms of a single parameter, which accounts for solubility, bulk flow, and stagnant fluid composition. A simple, explicit and exact expression was found to predict time-to-complete dissolution (TCD). An approximate solution was also found which tracks the exact case for low solubility conditions. |
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Keywords: | Dissolution Mass transfer Diffusion |
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