| 纳米银/壳聚糖复合水凝胶的原位制备、表征及抗菌性能研究 |
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| 引用本文： | 孔杰,李国强,叶菁芸,曾戎,屠美,赵剑豪.纳米银/壳聚糖复合水凝胶的原位制备、表征及抗菌性能研究[J].功能材料,2012,43(12):1662-1664. |
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| 作者姓名： | 孔杰 李国强 叶菁芸 曾戎 屠美 赵剑豪 |
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| 作者单位： | 1. 暨南大学材料科学与工程系,广东广州,510632
2. 暨南大学材料科学与工程系,广东广州510632;人工器官与材料教育部工程中心,广东广州510632 |
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| 基金项目： | 国家自然科学基金项目主任基金资助项目(31040027);暨南大学科研培育与创新基金资助项目(21609505) |
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| 摘 要： | 在壳聚糖/1,2-丙二醇凝胶中采用抗坏血酸原位还原硝酸银生成纳米银,进而通过碱液置换得到具有不同纳米银含量的物理交联的纳米银/壳聚糖复合水凝胶.紫外-可见光谱、X射线衍射图谱和低分辨率TEM照片的结果表明,复合水凝胶内形成了分散良好的纳米银.高分辨率TEM照片结果表明纳米银的直径在20～50nm之间,但其结晶状态并不均一.抗菌性实验证明,纳米银/壳聚糖复合水凝胶对大肠杆菌和金黄色葡萄球菌均有抗菌效果.
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| 关 键 词： | 壳聚糖 纳米银 水凝胶 抗菌 |
In situ preparation,characterization and antibacterial properties research of nano-silver/chitosan composite hydrogels |
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| KONG Jie
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LI Guo-qiang
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YE Jing-yun
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ZENG Rong
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TU Mei
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ZHAO Jian-hao.In situ preparation,characterization and antibacterial properties research of nano-silver/chitosan composite hydrogels[J].Journal of Functional Materials,2012,43(12):1662-1664. |
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| Authors: | KONG Jie LI Guo-qiang YE Jing-yun ZENG Rong TU Mei ZHAO Jian-hao |
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| Affiliation: | 1,2(1.Department of Materials Science and Engineering,Jinan University,Guangzhou 510632,China; 2.Engineering Research Center of Artificial Organs and Materials,Ministry of Education,Guangzhou 510632,China) |
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| Abstract: | Nano-silver particles were in situ prepared by reducing silver nitrate with ascorbic acid in chitosan/1,2-propylene glycol gel,and then nano-silver/chitosan composite physical hydrogels with different content of nano-silver were obtained by replacing 1,2-propanediol with alkaline solution.UV-visible spectra,XRD diffraction patterns and low resolution TEM images show that nano-silver particles with a good dispersion were formed in the composite hydrogels.High resolution TEM images indicate that the nano-silver particles were between 20-50nm in diameter,but its crystalline state was not uniform.Antimicrobial experiments illustrate the antibacterial properties of the nano-silver/chitosan composite hydrogel to Escherichiacoli and Staphylococcus aureus. |
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| Keywords: | chitosan nano-silver hydrogel antibacterial effect |
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