Expansion of cardiac ischemia/reperfusion injury after instillation of three forms of multi-walled carbon nanotubes |
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| Authors: | Rakhee N Urankar Robert M Lust Erin Mann Pranita Katwa Xiaojia Wang Ramakrishna Podila Susana C Hilderbrand Benjamin S Harrison Pengyu Chen Pu Chun Ke Apparao M Rao Jared M Brown Christopher J Wingard |
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| Affiliation: | (1) Department of Genetic Ecotoxicology, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, 142 20 Prague 4, Kragujevac, Czech Republic;(2) Department of Biochemistry, Faculty of Science, Charles University, Albertov 2030, 128 40, Prague 2, Czech Republic;(3) Czech Technical University in Prague, Prague 2, Czech Republic;(4) Veterinary Research Institute, Brno, Czech Republic |
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| Abstract: | Background Recently, we used cell-free assays to demonstrate the toxic effects of complex mixtures of organic extracts from urban air
particles (PM2.5) collected in four localities of the Czech Republic (Ostrava-Bartovice, Ostrava-Poruba, Karvina and Trebon)
which differed in the extent and sources of air pollution. To obtain further insight into the biological mechanisms of action
of the extractable organic matter (EOM) from ambient air particles, human embryonic lung fibroblasts (HEL12469) were treated
with the same four EOMs to assess changes in the genome-wide expression profiles compared to DMSO treated controls. |
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