互穿网络水凝胶角膜接触镜材料的合成及性能

通过高聚物分子设计的方法,运用互穿网络(IPN)技术,以吸水倍率为1.7的甲基丙烯酸β-羟乙酯(HEMA)水凝胶为基体材料,以吸水倍率为7~8的交联N-乙烯基吡咯烷酮(PVPP)颗粒为分散相,制备出了互穿程度不同的复合水凝胶角膜接触镜材料。利用SEM和TG分析仪对合成物的结构及热稳定性进行了表征。结果表明,m(PVPP颗粒)∶m(单体HEMA)=10∶90,以w(甘油或PEG400)=35%~45%作致孔剂,通过控制液体HEMA在PVPP颗粒中的渗透程度,可制得膨润率2%~5.3%、拉伸强度430~695 kPa、透光率>92%、含水质量分数45%左右的中等含水量的复合水凝胶角膜接触镜材料。DTG分析发现,在20~40℃,复合水凝胶的脱水速率随着互穿网络程度的提高而降低。

Synthesis and Characteristics of Interpenetrating Network Hydrogel for Contact Lens

The composite hydrogel for contact lens with different interpenetrating characteristic was prepared by the method of high polymer molecule design with β-hydroxyethyl methacrylate(HEMA) hydrogel as material,of which the water absorbency rate is 1.7,and PVPP particles as dispersing phase,of which the water absorbency rate is 7 to 8.The structure and the heat stability of product were characterized by SEM and TG analysis.The composite hydrogel for contact lens with expansion about 2% to 5.3%,the strength from 430 kPa to 695 kPa,high transparency over 92% and medium water content about 45% could be attained by controlling the penetrating degree of HEMA in PVPP with m(PVPP)∶m(HEMA)=10∶90,and w(glycerin or PEG400)=35%~45% as the porogen.The DTG analysis results show that at 20 ℃ to 40 ℃ the dehydration velocity increases with the decrease of degree of interpenetrating.