Effects of soy or milk protein durign a high-fat feeding challenge on oxidative stress, inflammation, and lipids in healthy men |
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Authors: | Christina G Campbell Blakely D Brown Danielle Dufner William G Thorland |
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Affiliation: | (1) Nutrition Research Laboratory (NRL), Department of Health and Human Development, Montana State University, 20 Herrick Hall, 59717 Bozeman, Montana;(2) Department of Health and Human Performance, University of Montana, 59812 Missoula, Montana;(3) Measurement by Design, 80129 Highlands Ranch, Colorado |
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Abstract: | Soy isoflavones may impede atherogenic processes associated with cardiovascular disease. Research suggests that the postprandial
generation of TG-rich remnants contributes to the development of atherosclerosis. The purpose of the current study was to
determine if 39 g soy (85 mg aglycone isoflavones, treatment) compared with 40 g milk protein (0 mg aglycone isoflavones,
control) in combination with a high-fat meal can modify postprandial, atherogenic-associated events and biomarkers for oxidative
stress, inflammation, and thrombosis. Fifteen healthy men (20–47 yr) participated in a double-blind cross-over meal-challenge
study occurring on two nonconsecutive days. The study meals consisted of two high-fat apple muffins consumed with either a
soy or milk shake (229 mL, 41% fat, 41% carbohydrate, and 18% protein). Blood samples were obtained at base-line (fasted)
and hours two, four, and six postprandial. Plasma TG significantly increased in both treatment and control meal challenges
compared with baseline. There were no significant differences (P>0.05) between treatment (soy) and control (milk) for ex vivo copper-induced LDL oxidation, serum C-reactive protein, serum interleukin-6 (IL-6), serum fibrinogen, or plasma lipids (total
cholesterol, HDL, LDL, TG). IL-6-concentrations significantly decreased as a function of time during either meal challenge
(P=0.005). These data suggest that consumption of soy or milk protein in conjunction with a high-fat meal does not acutely modify
postprandial oxidative stress, inflammation, or plasma lipid concentrations in young, healthy men. |
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