1-Phenyl-3-(aminomethyl)pyrroles as potential antipsychotic agents. Synthesis and dopamine receptor binding |
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| Authors: | A Thurkauf J Yuan X Chen JW Wasley R Meade KH Woodruff K Huston PC Ross |
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| Affiliation: | Department of Chemistry, Neurogen Corporation, Branford, Connecticut 06405, USA. |
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| Abstract: | A series of 1-phenyl-3-(aminomethyl)pyrroles were prepared in two steps from aniline and their affinities for D2, D3, and D4 dopamine receptor subtypes determined. A 15-fold selectivity for cloned human D4 receptors over cloned African Green monkey D2 receptors was observed with 1-(2-pyridyl)-4-[[3-(1-phenylpyrrolyl)]methyl]piperazine. |
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