Advanced control of crystallization processes |
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| Affiliation: | 1. School of Chemical Engineering, Purdue University, West Lafayette 47907-2100, United States;2. Department of Chemical Engineering, National Taiwan University, Taipei 106-07, Taiwan;1. Department of Catalysis and Chemical Reaction Engineering, National Institute of Chemistry, Hajdrihova 19, 1001 Ljubljana, Slovenia;2. Sandoz Development Centre Slovenia, Lek d.d., Kolodvorska 27, 1234 Mengeš, Slovenia;2. University of Leeds, Leeds, United Kingdom;3. Eli Lilly and Company, Indianapolis, IN, United States |
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| Abstract: | A key bottleneck in the production of pharmaceuticals and many other products is the formation of crystals from solution. The control of the crystal size distribution can be critically important for efficient downstream operations such as filtration and drying, and product effectiveness (e.g., bioavailability, tablet stability). This paper provides an overview of recent developments in the control of crystallization processes, including activities in sensor technologies, model identification, experimental design, process simulation, robustness analysis, and optimal control. |
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