| 4-氯吡啶的合成研究 |
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| 引用本文： | 钱豪,瞿军,陆文辉,张符,吴宏祥,宋祥波,朱幸丹,叶禹航.4-氯吡啶的合成研究[J].山东化工,2010,39(8):1-2,5. |
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| 作者姓名： | 钱豪 瞿军 陆文辉 张符 吴宏祥 宋祥波 朱幸丹 叶禹航 |
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| 作者单位： | [1]绍兴文理学院化学化工学院,浙江绍兴312000 [2]江苏省扬州普林斯化工有限公司,江苏扬州225002 |
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| 摘 要： | 以吡啶为原料,经过氧化氢-醋酸氧化,硫酸置换,再用硝酸钾/浓硫酸硝化得到关键中间体对硝基吡啶-N-氧化物,再用乙酰氯作为氯化试剂氯化得到对氯吡啶-N-氧化物,最后经铁粉还原得到对氯吡啶,产物含量97.6%,总收率47.1%。
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| 关 键 词： | 吡啶-N-氧化物 对硝基吡啶-N-氧化物 对氯吡啶-N-氧化物 对氯吡啶 |
Study on the Synthesis of 4-Chloropyridine |
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| QIAN Hao,QU Jun,LU Wen-Hui,ZHANG Fu,WU Hong-xiang,SONG Xiang-bo,ZHU Xing-dan,YE Yu-hang.Study on the Synthesis of 4-Chloropyridine[J].Shandong Chemical Industry,2010,39(8):1-2,5. |
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| Authors: | QIAN Hao QU Jun LU Wen-Hui ZHANG Fu WU Hong-xiang SONG Xiang-bo ZHU Xing-dan YE Yu-hang |
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| Affiliation: | QIAN Hao, QU Jun ,LU Wen - Hui ,ZHANG Fu, WU Hong - xiang, SONG Xiang - bo ,ZHU Xing - dan, YE Yu - hang ( 1. Shaoxing University, Shaoxing 312000,China; 2. Yangzhou Princechem Co. , Ltd. , Yangzhou 225000, China) |
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| Abstract: | A practical synthesis of p - chloropyridine was accomplished via the use of the critical intermediate p - nitropyridine - N - oxide after chlorination with acetyl chloride and then hydrogenation with Fe/AcOH, which can be obtained starting with pyridine after oxidation with peroxide -acetic acid, replacing with H2SO4 and then nitrating with KNO3/H2SO4 （98%）. The overall yield was 47.1% with the purity of 97.6%. |
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| Keywords: | pyridine - N - oxide 4 - nitropyridine - N - oxide 4 - chloropyridine - N - oxide 4 - chloropyridine |
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