| 多种新型手性磷酸催化剂的合成 |
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| 引用本文： | 朱利明,于芳.多种新型手性磷酸催化剂的合成[J].辽宁石油化工大学学报,2021,41(2):13-16. |
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| 作者姓名： | 朱利明 于芳 |
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| 作者单位： | 辽宁石油化工大学 石油化工学院，辽宁 抚顺 113001 |
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| 基金项目： | 国家自然科学基金项目(21402078)。 |
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| 摘 要： | 以R-联萘酚为原料,经过羟基保护、卤代、偶联、脱保护、磷酰化、水解等步骤高效合成多种新型手性磷酸催化剂.合成的手性磷酸催化剂以硝基取代基手性磷酸催化剂为主,因为硝基取代基的加入可以增加磷酸的酸性,为一些需要较强酸性催化体系的反应提供催化剂.该方法以较高的产率一次性合成10 g左右硝基取代的手性磷酸催化剂,为不对称催化反...
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| 关 键 词： | 手性磷酸 偶联反应 不对称 催化剂 |
| 收稿时间： | 2019-04-14 |
Synthesis of Various Novel Chiral Phosphoric Acid Catalysts |
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| Zhu Liming,Yu Fang.Synthesis of Various Novel Chiral Phosphoric Acid Catalysts[J].Journal of Liaoning University of Petroleum & Chemical Technology,2021,41(2):13-16. |
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| Authors: | Zhu Liming Yu Fang |
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| Affiliation: | School of Petrochemical Engineering， Liaoning Petrochemical University， Fushun Liaoning 113001， China |
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| Abstract: | A variety of novel chiral phosphoric acid catalysts were synthesized from R⁃binaphthol via hydroxyl protection, halogenation, coupling, deprotection, phosphorylation and hydrolysis. The chiral phosphoric acid catalysts synthesized were mainly chiral phosphoric acid catalysts with nitro substituents, because the addition of nitro substituents could increase the acidity of phosphoric acid and provide a catalyst for some reactions requiring a stronger acidic catalytic system. By our method, about 10 g of nitro⁃substituted chiral phosphoric acid catalyst could be synthesized in one time in a high yield, which provided great convenience for asymmetric catalytic reaction. |
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| Keywords: | Chiral phosphoric acid Coupling Asymmetry Catalysts |
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