可交联磷酰胆碱聚合物改性聚甲基戊烯中空纤维膜

通过自由基聚合反应制备了可交联磷酰胆碱聚合物(Poly(MPC-co-LMA-co-TSMA),PMLT).将该聚合物溶液涂覆在聚甲基戊烯中空纤维膜(PMPHFM)表面,经交联处理后可形成稳定的PMLT聚合物涂层,得到改性复合材料PMLT/PMPHFM.溶胀度测试表明PMLT聚合物膜具有良好的亲水性能,且溶胀度随着2-...

Cross-linkable phosphonylcholine polymer modified polymethylpentene hollow fiber membrane

Cross-linkable phosphorylcholine polymer(Poly(MPC-co-LMA-co-TSMA), PMLT) was prepared by free radical polymerization. Coating the copolymer solution on the surface of polymethylpentene hollow fiber membrane(PMPHFM) can form a stable polymer coating after the cross-linking treatment and obtain a modified composite material PMLT/PMPHFM. The swelling test shows that the PMLT copolymer has good hydrophilic properties, and the swelling degree increases with the increase of MPC content and temperature. ATR-FTIR and XPS analysis show that the polymer coating containing phosphorylcholine groups exist on the surface of PMLT/PMPHFM.SEM and fluorescence test results show that the surface of PMLT/PMPHFM is coated with a uniform polymer coating, and the coating could resist the dissolution of ethanol and SDS aqueous solution. Platelet adhesion and whole blood contact tests show that the coating could reduce platelet adhesion on the surface of PMPHFM, reduce the risk of blood clotting compared to bare PMPHFM. The results show that the PMLT copolymer has good hydrophilic property, and can be uniformly coated on the surface of PMPHFM to obtain a composite material PMLT/PMPHFM with good blood compatibility.