4-(2-苯并(噁)唑基)苯甲酸的氧化合成

采用气-液两相常压催化氧化法,以Co(AcO)2/Mn(AcO)2/NaBr为复合催化剂,合成了一种新型荧光增白剂中间体4-(2-苯并唑基)苯甲酸。考察了反应条件对收率的影响。实验结果表明,在催化剂质量分数1%、n(Co)∶n(Mn)=1∶3、溶剂质量分数80%、反应时间4 h、反应温度110℃、氧气速率15 mL.min-1条件下,单程收率达93%。脱水处理后反应液可循环使用5次,平均收率大于90%。

Oxidation Synthesis of 4-(2-Benzoxazolyl)benzoic Acid

A new fluorescent whitening agent intermediate 4-(2-benzoxazolyl)benzoic acid was synthesized by catalytic oxidation using Co(AcO)_(2)/Mn(AcO)_(2)/NaBr as catalyst under normal pressure.The influences of reaction conditions on yield were examined.Under the conditions of catalyst amount 1(wt)%,n(Co)∶n(Mn)=1∶3,solvent amount 80(wt)%,time 4 h,temperature 110 ℃,oxygen flow rate 15 mL·min~(-1),the yield was up to 93%.The catalyst could be reused for 5 times after filtration and dehydration,the average yield was over 90%.